Statins are contraindicated in pregnancy (pregnancy category X).
“Among over-the-counter pain relievers, only acetaminophen is considered safe throughout pregnancy (category B), and it is considered the analgesic of choice for pregnant patients (SOR C). Aspirin can cause premature closure of the ductus arteriosus, and while ibuprofen is considered a category B drug during the second trimester, it can also cause premature closure of the ductus arteriosus during the third trimester (SOR C).
Although pseudoephedrine is a category C drug, it is the decongestant of choice during pregnancy (SOR C). Chlorpheniramine is the antihistamine of choice during pregancy (SOR C), and is rated category B. Diphenhydramine is also rated category B, but has oxytocin-like effects at high doses.
Guaifenesin is associated with neural tube defects, and dextromethorphan is preferred for cough during pregnancy (SOR C).
References:
- Young SS, Blandino DA, Engle JP, et al: Appropriate Use of Common OTC Analgesics and Cough and Cold Remedies. American Academy of Family Physicians monograph, 2008.
http://www.aafp.org/online/etc/medialib/aafp_org/documents/news_pubs/mono/otc.Par.0001.File.tmp/OTCmonograph.pdf” ABFM