| Risk Factor | Points |
|---|---|
| Breast and ovarian cancer | |
| Mother | 10 |
| Sibling | 7 |
| Second-/third-degree relative | 5 |
| Breast cancer relative | |
| Parent | 4 |
| Sibling | 3 |
| Second-/third-degree relative | 2 |
| Male relative (add to above) | 2 |
| Breast cancer characteristics | |
| Onset at age 20–29 y | 6 |
| Onset at age 30–39 y | 4 |
| Onset at age 40–49 y | 2 |
| Premenopausal/perimenopausal | 2 |
| Bilateral/multifocal | 3 |
| Ovarian cancer relative | |
| Mother | 7 |
| Sibling | 4 |
| Second-/third-degree relative | 3 |
| Age at ovarian cancer onset | |
| <40 y | 6 |
| 40–60 y | 4 |
| >60 y | 2 |
| Age at prostate cancer onset | |
| <50 y | 1 |
| Age at colon cancer onset | |
| <50 y | 1 |
| Family total | |
| Referral† | ≥10 |
† Referral with a score of ≥10 corresponds to doubling of lifetime risk for breast cancer (22%).
Reference
https://www.uspreventiveservicestaskforce.org/Page/Document/RecommendationStatementFinal/brca-related-cancer-risk-assessment-genetic-counseling-and-genetic-testing