Nephritis, Acute interstitial

Clinic A/P, adults, Clinic A/P, Peds, Hospital A/P, Adults, Hospital A/P, Peds

Acute interstitial nephritis (AIN)

“AIN is an intrinsic renal cause of AKI. These patients are often nonoliguric. A history of recent medication use is key to the diagnosis, as cephalosporins and penicillin analogs are the most common causes.  Approximately one-third of patients present with a  maculopapular rash,  fever,  and arthralgias. Eosinophilia and sterile pyuria may also be seen in addition to eosinophiluria. Discontinuation of the offending drug is the cornerstone of management.” ABFM

Reference

Am  Fam  Physician 2012;86(7):631-639. 

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