Unconjugated
No Hemolysis
Physiologic jaundice
Breast milk jaundice
Infant of mother with diabetes
Internal hemorrhage
Polycythemia
Hypothyroidism
Immune thrombocytopenia
Gilbert syndrome,
Crigler-Najjar syndrome,
Pyloric stenosis
Hemolysis present
Blood group incompatibility: ABO, Rh factor, minor antigens
Infection
Thalassemia(Hemoglobinopathies)
G6PD,
Pyruvate kinase
Spherocytosis
Ovalocytosis
Conjugated
Cytomegalovirus infection,
Hyperalimentation cholestasis,
Neonatal hepatitis,
Sepsis,
TORCH infection,
Urinary tract infection
Biliary atresia,
Cystic fibrosis,
Hepatic infarction,
Inborn errors of metabolism (e.g., galactosemia, tyrosinosis)
Thinking through the differential
G6PD and pyruvate kinase = Red blood cell enzyme defects
Spherocytosis and ovalocytosis = Red blood cell membrane disorders
Further Reading / Reference
Am Fam Physician. 2008 May 1;77(9):1255-1262. A Practical Approach to Neonatal Jaundice. https://www.aafp.org/afp/2008/0501/p1255.html