Mycoplasma hominis infections: Drug of choice is a tetracycline (eg, doxycycline). Alternatives are clindamycin or a fluoroquinolone (e.g. moxifloxacin). Avoid macrolides, M. hominis is not susceptible to macrolides.
Ureaplasma spp. infections: Doxycycline in adults. Alternatives: Macrolides (eg, azithromycin) and fluoroquinolones (eg, moxifloxacin). Don’t use clindamycin because is not active against ureaplasmas.
When to treat: Treat disease, not colonization.
“Patients with disease thought to be caused by a Mycoplasma or Ureaplasma spp should be treated. In contrast, patients who are found to be colonized with one of these organisms, but who do not have clinical disease, do not require treatment. Given the difficulty in obtaining a diagnosis, patients are often treated empirically.”
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Mycoplasma genitalium – Treat with Moxifloxacin.
References
The following uptodate.com topic gives a great treatment of the subject.
https://www.uptodate.com/contents/mycoplasma-hominis-and-ureaplasma-urealyticum-infections