MCC is the most lethal of all skin cancers including melanoma; mortality is 33%
Most lesions presumed benign at time of dx (can resemble BCCs, asx, nontender, red or pink violaceous papules & nodules)
Acronym: AEIOU (Asx; Expanding rapidly, Immunosuppressed, Older than 50 y, UV exposed site on fair skin)
Workup/ treatment: Sentinel LN bx, surgery & radiation
