“Many drugs can cause lung disease. Amiodarone has been known to cause both bronchiolitis obliterans organizing pneumonia (BOOP) and interstitial pneumonitis. BOOP, also known as cryptogenic organizing pneumonia, is characterized by interstitial inflammation superimposed on the dominant background of alveolar and ductal fibrosis. This is a very distinctive pattern of lung response to exposure to several drugs, including amiodarone, bleomycin, gold, penicillamine, sulfasalazine, radiation, interferons, methotrexate, mitomycin C, cyclophosphamide, and cocaine. Interstitial pneumonitis is the most common manifestation of drug-induced lung disease. Drugs that can cause this include amiodarone, azathioprine, bleomycin, chlorambucil, methotrexate, phenytoin, statins, and sulfasalazine.
Ref: Broaddus VC, Mason RJ, Ernst JD, et al (eds): Murray & Nadel’s Textbook of Respiratory Medicine, ed 6. Elsevier Saunders, 2016, pp 71, 1275-1294.” ABFM critique