“Hyperuricemia is a relatively common finding in patients treated with a loop or thiazide diuretic and may, over a period of time, contribute to new-onset gouty arthritis or, more promptly, recurrence of established gout. Diuretics reduce urate excretion by both directly and indirectly increasing urate reabsorption and decreasing urate secretion; the effect is dose dependent. Treatment of asymptomatic hyperuricemia is not necessary. If diuretic-induced gout occurs, it is usually treated with a urate-lowering drug such as allopurinol.” Uptodate.com
“This may happen because diuretics increase urination, which reduces the amount of fluid in your body. But the remaining fluid is more concentrated, which can increase the risk that you’ll develop the crystals that cause gout. Some types of diuretics also reduce the kidneys’ excretion of urate, a component of uric acid.” Mayo Clinic
Read More
https://www.uptodate.com/contents/diuretic-induced-hyperuricemia-and-gout