- Graves disease causes Pretibial myxedema (whether it presents as hypo- or hyperthyroidism). Usually, it occurs in the lower legs and results from increased deposition of mucin.
- Diabetes mellitus can cause necrobiosis lipoidica, a lesion on the lower extremities;
- Hyperlipidemia can cause waxy papules; and
- Collagen vascular and ischemic disease can cause urticaria and/or ulceration.” ABFM