• Graves disease causes Pretibial myxedema (whether it presents as hypo- or hyperthyroidism). Usually, it occurs in the lower legs and results from increased deposition of mucin.
  • Diabetes mellitus can cause necrobiosis lipoidica, a lesion on the lower extremities;
  • Hyperlipidemia can cause waxy papules; and
  • Collagen vascular and ischemic disease can cause urticaria and/or ulceration.” ABFM
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