Don’t combine an ACE inhibitor and an ARB

HealthCare

They are equally effective and helpful in patients with DM, atherosclerosis, and end-organ damage. However, combining them leads to higher creatinine levels PLUS increased likelihood that the patient would need dialysis!

Clinical manifestations of sickle cell disease

HealthCare

Sickle cell anemia is caused by a recessive beta-globin mutation leads to structurally abnormal hemoglobin (HbS). 8% of African Americans are heterozygotes (“sickle trait”; usually w/o sx). 1 in 400 are homozygotes (sickle cell disease) Deoxygenated HbS polymerizes...

Drug contraindications

HealthCare

In older adults, coprescription of clarithromycin or erythromycin with a statin that is metabolized by CYP 3A4 (atorvastatin, simvastatin, lovastatin) increases the risk of statin toxicity. Don’t prescribe clarithromycin to an older adult who is on Simvastatin....