Colchicine

How does Colchicine work to treat acute gout? In gout, colchicine concentrates in neutrophils (PMNs) and inhibits microtubule formation. This prevents neutrophils from migrating to inflamed joints and exerting their activity there. Neutrophils that migrate to the...

Hypertension in pregnancy (Drug Choices)

Labetalol = 1st line. Labetalol 100-400 mg BID. Start 100 mg PO BID. May increase by 100 mg BID q2-3 days. Max dose: 2400 mg /day. Methyldopa 250 -500 mg PO BID. Start 250 mg PO BID, then adjust q2 days. Max 3000 mg /day. Nifedipine extended-release 30 to 90 mg daily....