Autosomal dominant polycystic kidney disease (ADPCKD)

Clinic A/P, adults, Clinic A/P, Peds, Hospital A/P, Adults

-ADPCKD is the most common genetic kidney disease and accounts for 4.7% of ESRD cases in the U.S.
-Many patients with ADPCKD are asymptomatic, but early symptoms may include flank pain, gross hematuria, or recurrent UTIs.
-Hypertension is the most common extrarenal manifestation of ADPCKD.
Treatment
-An ACE-I/ARB are recommended first-line treatment for HTN in these patients.

 

Further Reading

N Engl J Med 2008;359(14):1477-1485. Autosomal dominant polycystic kidney disease.

Am Fam Physician 2014;90(5):303-307. Autosomal dominant polycystic kidney disease.

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