Assessing severity and initiating therapy in children who are not currently taking long-term control medication.
The level of severity is determined by both impairment and risk.
NB: Kids 0-4 years old can’t do spirometry, so it’s not included.
Components of severity Classification of asthma severity (0 to 4 years of age)
Intermittent Persistent
Mild Moderate Severe
Impairment Symptoms ≤2 days/week >2 days/week but not daily Daily Throughout the day
Nighttime awakenings 0 1 to 2 times/month 3 to 4 times/month >1 time/week
Short-acting beta2 agonist use for symptom control (not prevention of EIB) ≤2 days/week >2 days/week but not daily Daily Several times per day
Interference with normal activity None Minor limitation Some limitation Extremely limited
Risk Exacerbations requiring oral systemic glucocorticoids 0 to 1/year ≥2 exacerbations in six months requiring oral systemic glucocorticoids, or ≥4 wheezing episodes/one year lasting >1 day AND risk factors for persistent asthma
Consider severity and interval since last exacerbation
Frequency and severity may fluctuate over time
Exacerbations of any severity may occur in patients in any severity category
Recommended step for initiating treatment Step 1 Step 2 Step 3 and consider a short course of oral systemic glucocorticoids
In two to six weeks, depending on severity, evaluate the level of asthma control that is achieved. If no clear benefit is observed in four to six weeks, consider adjusting therapy or alternative diagnoses.
  • Assess impairment domain by patient’s/caregiver’s recall of the previous 2 to 4 weeks.
  • Is asthma better or worse since the last visit?
  • Assign severity to the most severe category in which any feature occurs.
  • At present, data are inadequate to correlate frequencies of exacerbations with different levels of asthma severity. For treatment purposes, patients who had ≥2 exacerbations requiring oral systemic glucocorticoids in the past 6 months, or ≥4 wheezing episodes in the past year, and who have risk factors for persistent asthma may be considered the same as patients who have persistent asthma, even in the absence of impairment levels consistent with persistent asthma. EIB: exercise-induced bronchospasm.
References / Resources
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